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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STXBP1
All Species:
19.13
Human Site:
S594
Identified Species:
30.06
UniProt:
P61764
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61764
NP_001027392.1
594
67569
S594
K
T
D
E
E
I
S
S
_
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001152683
595
67000
A593
D
K
K
L
E
D
I
A
L
P
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001095617
580
66142
S580
K
T
D
E
E
I
S
S
_
_
_
_
_
_
_
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q64324
593
66339
A591
D
Q
K
L
E
G
V
A
L
P
_
_
_
_
_
Rat
Rattus norvegicus
P61765
594
67550
S594
K
T
D
E
E
I
S
S
_
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508183
589
67400
S580
F
R
E
F
T
R
V
S
F
E
D
Q
A
P
T
Chicken
Gallus gallus
Q6R748
594
67454
S594
K
T
D
E
E
I
S
S
_
_
_
_
_
_
_
Frog
Xenopus laevis
NP_001093335
595
67691
S595
K
T
D
D
E
S
S
S
_
_
_
_
_
_
_
Zebra Danio
Brachydanio rerio
NP_001020353
591
67111
E591
A
M
N
K
P
D
E
E
_
_
_
_
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07327
597
67832
Honey Bee
Apis mellifera
XP_396375
585
66573
Nematode Worm
Caenorhab. elegans
P34815
673
76715
D672
R
D
L
N
K
P
R
D
I
_
_
_
_
_
_
Sea Urchin
Strong. purpuratus
NP_999834
593
68046
G591
L
S
D
L
R
E
L
G
S
N
_
_
_
_
_
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZ77
662
75299
S635
E
V
I
L
G
S
S
S
F
L
D
P
L
T
F
Baker's Yeast
Sacchar. cerevisiae
P30619
724
83462
K647
Q
N
P
R
E
F
F
K
F
K
E
D
Q
R
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.8
97.6
N.A.
N.A.
62.7
100
N.A.
93.4
97.9
92.4
86.5
N.A.
63.4
63.9
52.1
60.9
Protein Similarity:
100
81.1
97.6
N.A.
N.A.
80.6
100
N.A.
96.1
99.4
97.9
94.6
N.A.
78
79.6
67.4
77.7
P-Site Identity:
100
10
100
N.A.
N.A.
10
100
N.A.
6.6
100
75
0
N.A.
0
0
0
10
P-Site Similarity:
100
20
100
N.A.
N.A.
20
100
N.A.
13.3
100
87.5
25
N.A.
0
0
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
42.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
14
0
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
7
40
7
0
14
0
7
0
0
14
7
0
0
0
% D
% Glu:
7
0
7
27
54
7
7
7
0
7
7
0
0
0
0
% E
% Phe:
7
0
0
7
0
7
7
0
20
0
0
0
0
0
7
% F
% Gly:
0
0
0
0
7
7
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
7
0
0
27
7
0
7
0
0
0
0
0
0
% I
% Lys:
34
7
14
7
7
0
0
7
0
7
0
0
0
0
0
% K
% Leu:
7
0
7
27
0
0
7
0
14
7
0
0
7
0
0
% L
% Met:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
7
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
7
0
7
7
0
0
0
14
0
7
0
7
0
% P
% Gln:
7
7
0
0
0
0
0
0
0
0
0
7
7
0
7
% Q
% Arg:
7
7
0
7
7
7
7
0
0
0
0
0
0
7
0
% R
% Ser:
0
7
0
0
0
14
40
47
7
0
0
0
0
0
0
% S
% Thr:
0
34
0
0
7
0
0
0
0
0
0
0
0
7
7
% T
% Val:
0
7
0
0
0
0
14
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
40
47
67
67
67
67
67
% _